CAS 71597-85-8 4-Hydroxyphenylboronic acid - Materials / Alfa Chemistry

NAVIGATION

4-Hydroxyphenylboronic acid

PRICE INQUIRY

Catalog Number

ACM71597858

CAS Number

71597-85-8

Product Name

4-Hydroxyphenylboronic acid

Category

Salt

Synonyms

p-Hydroxy-benzeneboronic acid

IUPAC Name

(4-hydroxyphenyl)boronic acid

Molecular Weight

137.93

Molecular Formula

C6H7BO3

Canonical SMILES

B(C1=CC=C(C=C1)O)(O)O

InChI

InChI=1S/C6H7BO3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8-10H

InChI Key

COIQUVGFTILYGA-UHFFFAOYSA-N

Boiling Point

351.4 °C

Melting Point

230 °C

Purity

98%+

Density

1.32 g/ml

Application

4-Hydroxyphenylboronic acid serves as a versatile reactant with a variety of applications in organic synthesis and pharmaceuticals. It is prominently used in Suzuki-Miyaura and Stille coupling reactions, as well as in palladium-catalyzed aminocarbonylation and cross-coupling procedures, including the Suzuki reaction aimed at creating bio-supported palladium nanoparticles, which act as phosphine-free catalysts. Additionally, it facilitates Cu2O-catalyzed aerobic oxidative cross-coupling of tetrazoles. Beyond these applications, 4-Hydroxyphenylboronic acid contributes to the development of bioactive compounds, such as promoting PDK1 inhibitory activity, which is crucial in inhibiting cancer cell growth and tumor progression. It is instrumental in the synthesis of rod-like dendronized polymers through the macromonomer approach by living ROMP, as well as in crafting estrone-derived cyclopamine analogs, which function as Sonic Hedgehog signaling inhibitors for anti-cancer therapeutics. Furthermore, it aids the preparation of enzymatic inhibitors targeting Gram-negative bacterial infections and the formation of oligoarenes through Suzuki-Miyaura palladium-catalyzed cross-coupling, underscoring its broad utility in scientific research and medicinal chemistry.

Complexity

99.2

Covalently-Bonded Unit Count

Exact Mass

138.048824g/mol

Formal Charge

Heavy Atom Count

Monoisotopic Mass

138.048824g/mol

Rotatable Bond Count

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