HO-PEG8-OH - Materials / Alfa Chemistry

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HO-PEG8-OH

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Catalog Number

ACMA00013991

Product Name

HO-PEG8-OH

Category

Poly(ethylene glycol) and Poly(ethylene oxide)

Description

Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation.

IUPAC Name

2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol

Molecular Weight

370.44g/mol

Molecular Formula

C16H34O9

Canonical SMILES

C(COCCOCCOCCOCCOCCOCCOCCO)O

InChI

InChI=1S/C16H34O9/c17-1-3-19-5-7-21-9-11-23-13-15-25-16-14-24-12-10-22-8-6-20-4-2-18/h17-18H,1-16H2

InChI Key

GLZWNFNQMJAZGY-UHFFFAOYSA-N

Application

Activated PEG derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. PEGylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of PEG improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. In addition to PEGylation, activated PEG derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity.

Complexity

210

Covalently-Bonded Unit Count

EC Number

225-856-4

Exact Mass

370.220283g/mol

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Formal Charge

Heavy Atom Count

Monoisotopic Mass