CAS 33342-05-1 Gliquidone, 98% - Materials / Alfa Chemistry

NAVIGATION

Gliquidone, 98%

PRICE INQUIRY

Catalog Number

ACM33342051

CAS Number

33342-05-1

Product Name

Gliquidone, 98%

Category

Other Glass and Ceramic Materials

Description

Solid

IUPAC Name

1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxoisoquinolin-2-yl)ethyl]phenyl]sulfonylurea

Molecular Weight

527.6g/mol

Molecular Formula

C27H33N3O6S

Canonical SMILES

CC1(C2=C(C=C(C=C2)OC)C(=O)N(C1=O)CCC3=CC=C(C=C3)S(=O)(=O)NC(=O)NC4CCCCC4)C

InChI

InChI=1S/C27H33N3O6S/c1-27(2)23-14-11-20(36-3)17-22(23)24(31)30(25(27)32)16-15-18-9-12-21(13-10-18)37(34,35)29-26(33)28-19-7-5-4-6-8-19/h9-14,17,19H,4-8,15-16H2,1-3H3,(H2,28,29,33)

InChI Key

LLJFMFZYVVLQKT-UHFFFAOYSA-N

Melting Point

180-182;181.0 °C;181°C

Solubility

2.20e-03 g/L;69.5 [ug/mL]

Application

Gliquidone, 98% is designed as an effective anti-diabetic agent aimed at addressing the complexities of diabetes management. Primarily used to treat conditions like hypoglycemia, which heightens the risk of diabetic cardiovascular disease, and diabetic nephropathy, Gliquidone functions as a second-generation sulfonylurea. It acts by selectively inhibiting ATP-sensitive potassium channels in pancreatic β-cells, thereby promoting insulin release and reducing blood glucose levels. Its role extends beyond glucose modulation, as it also acts as an agonist for the peroxisome proliferator-activated receptor γ (PPARγ), further enhancing its therapeutic impact. In animal studies, Gliquidone has demonstrated significant efficacy by lowering various biochemical markers such as blood glucose, serum alkaline phosphatase, and hepatic lipid peroxidation, while boosting hepatic glutathione levels, highlighting its comprehensive approach in managing diabetes and its associated complications.

Complexity

948

Covalently-Bonded Unit Count

EC Number

251-463-2

Exact Mass

527.209007g/mol

Formal Charge

Heavy Atom Count

Log P

4.5

MeSH Entry Terms