CAS 9004-57-3 Ethyl Cellulose [45-55mPa·s, 5% in Toluene + Ethanol (80:20) at 25°C]

NAVIGATION

Ethyl Cellulose [45-55mPa·s, 5% in Toluene + Ethanol (80:20) at 25°C]

PRICE INQUIRY

Catalog Number

ACM9004573-18

CAS Number

9004-57-3

Product Name

Ethyl Cellulose [45-55mPa·s, 5% in Toluene + Ethanol (80:20) at 25°C]

Category

Polymers

IUPAC Name

(2R,3R,4S,5S,6R)-5-[(2S,3R,4S,5S,6R)-4,6-bis(ethoxymethyl)-3,5-dihydroxyoxan-2-yl]oxy-3-ethoxy-6-(hydroxymethyl)oxane-2,4-diol

Molecular Weight

440.5g/mol

Molecular Formula

C19H36O11

Canonical SMILES

CCOCC1C(C(OC(C1O)OC2C(OC(C(C2O)OCC)O)CO)COCC)O

InChI

InChI=1S/C19H36O11/c1-4-25-8-10-13(21)12(9-26-5-2)29-19(14(10)22)30-16-11(7-20)28-18(24)17(15(16)23)27-6-3/h10-24H,4-9H2,1-3H3/t10-,11+,12+,13-,14+,15-,16+,17+,18+,19-/m0/s1

InChI Key

GJQHNBFXPPDVQM-KSQRYXQLSA-N

Melting Point

240-255 °C

Density

1.07-1.18

Solubility

INSOL IN GLYCERIN AND PROPYLENE GLYCOL;FREELY SOL IN MIXT OF AROMATIC HYDROCARBONS WITH ALCOHOL;Has an ethyl degree of substitution (DS) in the range of ~2.2 - 2.7. ... water soluble at DS ~1.2 ... Above a DS of ca 2.5, soluble in many polar solvents.;Soluble in most organic liquids

Application

Ethyl cellulose [45-55 mPa·s, 5% in Toluene + Ethanol (80:20) at 25°C] serves multiple purposes in various formulations. As a versatile polymer, it is employed in pharmaceutical applications primarily as a hydrophobic coating agent for tablets and granules, where it modifies drug release, masks unpleasant tastes, and enhances stability by inhibiting oxidation. Its capacity to form water-insoluble films when dissolved in organic solvents or aqueous dispersions makes it valuable for creating modified-release dosage forms. Additionally, higher-viscosity grades of ethyl cellulose contribute to the production of strong, durable films and are used in drug microencapsulation, allowing control over drug release by adjusting wall thickness and surface area. In tablet formulations, ethyl cellulose acts as a binder, promoting the formation of hard tablets with low friability, although dissolution may require optimization. Beyond pharmaceuticals, ethyl cellulose is utilized as a thickening agent in topical formulations like creams, lotions, and gels, and it stabilizes emulsions. Its applications extend to cosmetics and food products, showcasing its versatility as a film former and thickener.

Color/Form

WHITE NEEDLES FROM BENZENE;FREE-FLOWING, WHITE TO LIGHT TAN POWDER;AVAILABLE COMMERCIALLY AS CLEAR FILM OR SHEET;White, granular, thermoplastic solid

Complexity

481

Covalently-Bonded Unit Count

EC Number

618-384-9

Exact Mass

440.225762g/mol

Formal Charge

Heavy Atom Count

Log P

5.5 (LogP)

Monoisotopic Mass

440.225762g/mol

Other Experimental

MEDIUM-TYPE VISCOSITY GRADE CONTAINS LESS THAN 46.5% ETHOXY GROUPS; STANDARD-TYPE VISCOSITY GRADE CONTAINS 46.5% OR MORE;Lowest density of commmercial cellulose plastics; high dielectric strength; softening point 100-130 °C;Inert to alkalies and dilute acids; compatible with resins, waxes, oils, and plasticizers;ODORLESS & TASTELESS /CELLULOSE ETHERS/;The ethoxyl content of ethyl cellulose affects thermal behavior.;Sol in ethyl acetate, ethylene dichloride, benzene, toluene, xylene, butyl acetate, acetone, methanol, ethanol, butanol, carbon tetrachloride. /47% product/;FREELY SOL IN CHLOROFORM, CYCLOHEXANE FREELY SOL IN METHYL ACETATE /MEDIUM VISCOSITY/;/Ethyl cellulose/ forms films of good thermostability and excellent flexibility and toughness.

Refractive Index

Index of refraction: 1.47;FORMS FILMS THAT HAVE REFRACTIVE INDEX OF ABOUT 1.47

Rotatable Bond Count

Stability

Very stable chemically /Cellulose ethers/

XLogP3

-2.4

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