CAS 1510-21-0 Cholesteryl hemisuccinate - Materials / Alfa Chemistry

NAVIGATION

Cholesteryl hemisuccinate

PRICE INQUIRY

Catalog Number

ACM1510210

CAS Number

1510-21-0

Product Name

Cholesteryl hemisuccinate

Structure

Category

Liquid Crystal (LC) Materials

Synonyms

Cholesteryl hydrogen succinate

Description

Cholesteryl hemisuccinate is a with hepatoprotective an anticancer activity. Cholesteryl hemisuccinate inhibits Acetaminophen (AAP, HY-66005) hepatotoxicity, and prevents AAP-induced hepatic apoptosis and necrosis. Cholesteryl hemisuccinate inhibits DNA polymerase and DNA topoisomerase to inhibit DNA replication and repair and cell division. Thus, Cholesteryl hemisuccinate inhibits tumor growth.

IUPAC Name

4-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-4-oxobutanoic acid

Molecular Weight

486.7

Molecular Formula

C31H50O4

Canonical SMILES

CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C

InChI

InChI=1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1

InChI Key

WLNARFZDISHUGS-MIXBDBMTSA-N

Boiling Point

586.0±43.0 °C (Predicted)

Melting Point

178 °C

Flash Point

179.6°C

Purity

≥95%

Density

1.06±0.1 g/cm³ (Predicted)

Solubility

Chloroform: 10 mg/mL

Appearance

A crystalline solid

Application

Cholesteryl hemisuccinate serves as a versatile compound with diverse applications in biochemical and pharmacological studies. It is primarily used as a detergent to replace cholesterol in protein crystallography, which aids in the structural analysis of proteins. Its function extends to stabilizing unilamellar vesicles and liposomes, essential for various drug delivery systems involving anticancer drugs, antibiotics, and oligonucleotides. Additionally, cholesteryl hemisuccinate exhibits anticancer properties by inhibiting the growth of certain leukemia cells. It also acts as an emulsifying agent, facilitating the solubilization of proteins, such as chemokine receptor 1 and erythrocyte ghosts, enhancing their study and application in research and therapeutic contexts.

Storage

Powder-20°C, 3 years; 4°C, 2 years; In solvent-80°C, 6 months; -20°C, 1 month.

Assay

0.99

Complexity

815

EC Number

216-148-6

Exact Mass

486.37091007

Formal Charge

Heavy Atom Count