Catalog Number
ACMA00044165
Product Name
Chlorotrityl Polystyrene, Type2
Category
Chlorotrityl Polystyrene Resins
Synonyms
Trityl Chloride Resin
Application
This highly acid labile resin is useful for the immobilization of alcohols, amines and carboxylic acids. Cleavage is in general achieved by using either 1-5% TFA in CH₂Cl₂ (containing 5% triisopropylsilane) or acetic acid.
This resin can also be used in Fmoc peptide synthesis under basic acylation conditions. Carboxylic acids can be released under very mild acidic conditions by treatment with AcOH/TFE/DCM or HFIP in DCM. Completely protected peptides are generated under this conditions.
Storage Conditions
Stable under recommended storage conditions. Conditions to Avoid: Strong oxidizing reagents