Chloro-(2'-chloro)trityl Polystyrene, Type3

Name: Chloro-(2'-chloro)trityl Polystyrene, Type3
SKU: ACMA00044169
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Catalog NumberACMA00044169

CategoryChloro-(2'-chloro)trityl Polystyrene Resins

Chloro-(2'-chloro)trityl Polystyrene, Type3

Description

A very acid-sensitive resin is suitable for the synthesis of protected peptide fragments by the Fmoc strategy. In particular suitable for the preparation of C-terminal prolyl and cysteinyl peptides. Cleavage from this resin is achieved by using 1-95% TFA in CH₂Cl₂ (containing 8% triisopropylsilane), AcOH/CF₃OH/CH₂Cl₂, 0.5% TFA or hexafluoroisopropanol.

Application

Recently, this resin has been used in cyclization reactions under Heck reaction conditions, the solid phase synthesis of b-peptides via the Arndt-Eistert homologation of Fmoc-protected amino acid diazoketones and in Mannich reactions of alkynes, secondary amines and aldehydes in the presence of a copper (I) salt leading to the corresponding aminomethylalkynyl adducts.
This resin can also be used in Fmoc peptide synthesis. Carboxylic acids can be released under very mild acidic conditions by treatment with AcOH/TFE/DCM or HFIP in DCM. Completely protected peptides are generated under these conditions.

Form

Solid

Packaging

5g, 25g, 100g

Size

250-315 µm, 400-450 µm, 500-560 µm

Storage Conditions

Stable under recommended storage conditions. Conditions to Avoid: Strong oxidizing reagents

If you have any other questions or need other size, please get a quote.

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ACMA00044169
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