4-(Trifluoromethoxy)phenylmagnesium bromide solution

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Catalog Number

ACMA00015512

Product Name

4-(Trifluoromethoxy)phenylmagnesium bromide solution

Category

Salt

Application

The purpose of 4-(Trifluoromethoxy)phenylmagnesium bromide solution is to serve as a versatile reagent in various organic synthesis reactions. It is primarily used in the preparation of chromanol derivatives, which are a novel class of CETP inhibitors aimed at treating cardiovascular disease. Additionally, this solution plays a key role in Pd-catalyzed cross-coupling reactions and the synthesis of indazole-pyridine derivatives. These derivatives function as protein kinase B/Akt inhibitors and are designed to have reduced hypotensive effects. The solution's utility extends through its involvement in the Stille coupling, Mitsunobu reaction, and copper-catalyzed aziridine ring-opening reactions, highlighting its significance in advanced pharmaceutical applications. As a Grignard reagent, it is essential for forming carbon-carbon bonds, making it an indispensable component in the creation of complex organic molecules.

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