CAS 99-92-3 4-Aminoacetophenone - Materials / Alfa Chemistry

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4-Aminoacetophenone

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Catalog Number

ACM99923

CAS Number

99-92-3

Product Name

4-Aminoacetophenone

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Synthesis And Application of 4-Aminoacetophenone-Derived Schiff Base Complexes

Sarto, Luis Eduardo, et al. Anticancer Research, 2019, 39(12), 6693-6699.

Schiff bases derived from 4-aminoacetophenone can be further used to develop anticancer drugs against melanoma when complexed with Pd(II) complexes. The prepared 4-aminoacetophenone-derived Schiff base palladium(II) complex exhibits positive cytotoxic effects on MDA-MB-435, an aggressive melanoma cancer cell line, and may be a candidate for antitumor drug development Promising candidates.
Synthesis of 4-aminoacetophenone-derived Schiff base ligands
· A solution of p-anisaldehyde (8.28 mmol), terephthaldehyde (4.13 mmol) or trans-cinnamaldehyde (8.26 mmol) in ethanol (5 ml), was added dropwise to a solution of of 4- aminoacetophenone (8.28 mmol) in ethanol (30 ml), to yield the L1, L2 and L3 ligands respectively.
· The reaction mixture was stirred at room temperature for 4 h. After coolling for 24 h, at -10˚C, a pellet was formed which was filtered off, washed (with ethanol, water and ethyl ether) and vacuum-dried.

Synthesis of Azo Dyes Derived from 4-Aminoacetophenone

Al-Obaidi,et al. Journal of Biochemical Technology, 2018, 9(4), 33.

New azo dyes can be synthesized through the coupling reaction of p-aminoacetophenone and phenolic formaldehyde. For example, products A1, A2, A4 and A5 are dyes used in the dyeing process and are suitable for wool, cotton and sawdust. In addition to the dyeing process, the dyeing compounds exhibit moderate to good wash fastness and a noticeable smoothness after washing.
Preparation of 4-aminoacetophenone-derived azo compounds
· Preparing diazonium salt
2 ml Conc. HCl with 10 ml distilled water were dissolved in 0.54 g-0.004 mol of p-Amino acetophenone at 0-5 ° C. In the second flask solution was prepared by dissolving 0.200 g of sodium nitrite in 5 ml of distilled water at 0-5 °C; then the first solution was added to the second solution as batches at 0-5 °C.
· Coupling Reaction
In 5 ml of 35% NaOH 0.360 g - 0.004 mol of phenol was dissolved at 0-5 °C and then diazonium salt was added with stirrer at 0-5 °C to obtained yellow precipitate. Finally, the precipitate was collected and the yield was calculated.

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